The indicate constant condition volume of distribution (Vss) for sildenafil is 105 L, indicating distribution into the tissues. Sildenafil and its major circulating N-desmethyl metabolite are both of those close to ninety six% bound to plasma proteins. Protein binding is unbiased of overall drug con

Some clients seasoned a sudden reduce or loss of hearing when they took sildenafil or other medicines that are comparable to sildenafil. It's not known if the Listening to decline was a result of the medication. If you encounter a sudden loss of hearing, from time to time with ringing in the ear